Raymond Garrison is only sure about one thing: that he is not Raymond Garrison. Having survived death, with no recollections, his mind, body and soul have been remade. A mysterious organization, Project Lazarus, has formatted his body with nanite enhancements that grant him superhuman abilities, but also leave him more machine than man, and more monster than human. After escaping his captors, Bloodshot now searches for answers as to who he is, destroying anything that attempts to stop him.